Imposed mutational meltdown as an antiviral strategy
نویسندگان
چکیده
منابع مشابه
An experimental evaluation of drug-induced mutational meltdown as an antiviral treatment strategy.
The rapid evolution of drug resistance remains a critical public health concern. The treatment of influenza A virus (IAV) has proven particularly challenging, due to the ability of the virus to develop resistance against current antivirals and vaccines. Here, we evaluate a novel antiviral drug therapy, favipiravir, for which the mechanism of action in IAV involves an interaction with the viral ...
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In small or repeatedly bottlenecked populations, mutations are expected to accumulate by genetic drift, causing fitness declines. In mutational meltdown models, such fitness declines further reduce population size, thus accelerating additional mutation accumulation and leading to extinction. Because the rate of mutation accumulation is determined partly by the mutation rate, the risk and rate o...
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When a new mdividual is formed (independently of the reproduction process) it inherits harmful iuutations. Moreover, new mutations are acquired even in the genetic code formation, most of them deleterious ones. This might lead to a time decay in the mean fitness of the whole population that, for long enough time, ,vould produce the extinction of the
متن کاملThe mutational meltdown in asexual populations.
Loss of fitness due to the accumulation of deleterious mutations appears to be inevitable in small, obligately asexual populations, as these are incapable of reconstituting highly fit genotypes by recombination or back mutation. The cumulative buildup of such mutations is expected to lead to an eventual reduction in population size, and this facilitates the chance accumulation of future mutatio...
متن کاملQuantifying the mutational meltdown in diploid populations.
Mutational meltdown, in which demographic and genetic processes mutually reinforce one another to accelerate the extinction of small populations, has been poorly quantified despite its potential importance in conservation biology. Here we present a model-based framework to study and quantify the mutational meltdown in a finite diploid population that is evolving continuously in time and subject...
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ژورنال
عنوان ژورنال: Evolution
سال: 2020
ISSN: 0014-3820,1558-5646
DOI: 10.1111/evo.14107